Activation of Testosterone by Higher Fatty Acids and Their Acid Sodium Salts*
نویسنده
چکیده
The influence of male sex hormones on the development of the accessory sex organs in the rat can be enhanced: (a) by esterification with certain lower fatty acids (1, 2) ; (b) by administering the hormone together with either certain higher fatty acids (3) or high molecular weight saturated primary alcohols ((3) p. 1974) ; the injection of the hormone and the second component must be made at the same time and site to obtain the desired effect. It has further been found that the free hormone only can be activated, and that a combination of hormone esters with fatty acids appears to bring about no further increase of the physiological effect ((1) p. 1986, (2)). Laqueur and his collaborators found that an activating factor, the so called X substance, is present in various tissues (4). Tschopp and coworkers succeeded in isolating palmitic acid from the X substance fraction of testes by means of the chromatographic adsorption technique (5). They also investigated the activating effect of a number of naturally occurring fatty acids and found palmitic acid to be the most effective (3). In an earlier paper Ehrenstein and Britton (6) describe the isolation of an acid sodium salt of palmitic acid, C15H31COOH .C1r,H31COONa, from adrenal glands. Its possible action as an activator of male sex hormones is there discussed. Evidence has now been obtained that this sali is not originally present in the adrenal tissues. It is apparently formed by the permutit treatment employed during the preparation of corticoadrenal
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تاریخ انتشار 2000